Research output per year
Research output per year
Personal profile
Research interests
Personal profile
About
Dr. Sepehrimanesh is a Tenure-track Assistant Professor in the School of Biological Sciences at Louisiana Tech University. His research focuses on the molecular and cellular mechanisms underlying neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS) and other neurological disorders. His work integrates stem cell biology, neurobiology, bioinformatics, and advanced cell culture models to investigate how cellular dysfunction contributes to neurodegeneration and neurovascular impairment.
Dr. Sepehrimanesh leads research aimed at understanding the roles of oxidative stress, mitochondrial dysfunction, autophagy, and neuroinflammation in neurological diseases. His laboratory employs human induced pluripotent stem cell (hiPSC)-derived neural models, transcriptomic analyses, and innovative co-culture systems to study interactions among cells of the nervous system and neurovascular unit. In addition to his research activities, he is actively involved in teaching undergraduate and graduate courses in molecular biology, immunology, and neuroscience, while mentoring students and fostering interdisciplinary collaborations. His work has been supported by competitive research grants and has contributed to advancing knowledge in neuroscience and translational biomedical research.
Education:
DVM, Veterinary Medicine, Shiraz University, 2003-2010
Ph.D., Biochemistry, Shiraz University, 2010-2014
Postdoc fellow, Biology, University of Louisiana at Lafayette, 2019-2021
Postdoc Fellow, Neuroscience, Louisiana State University Health Sciences Center, 2022-2024
Please visit Dr. Sepehrimanesh Lab
Teaching
- Molecular Biology
- Molecular Neurobiology
- Immunology
- Animal Physiology
Consultancy
American Society of Biochemistry and Molecular Biology
Other work
- Elucidate the pathomechanisms of amyotrophic lateral sclerosis (ALS) by utilizing human-induced pluripotent stem cell-derived motor neurons (hiPSC-MNs).
- Investigates the potential carcinogenic and neurodegenerative effects of cell phone radiation through mammalian cell culture and animal models.
- Use mouse models and stem cells to study neurodegenerative diseases, with a particular focus on autophagy and apoptosis pathways.
Previous employer
Department of Biochemistry and Molecular Biology, Louisiana State University Health Science Center at Shreveport
Publications
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 4 Quality Education -
SDG 8 Decent Work and Economic Growth -
SDG 10 Reduced Inequalities -
SDG 17 Partnerships for the Goals
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Comparative analysis of chemical and lentiviral approaches in the generation of human induced pluripotent stem cell-derived motor neurons
Sepehrimanesh, M., Xu, W. & Ding, B., Jul 1 2026, In: Neural regeneration research. 21, 7, p. 2968-2974 7 p.Research output: Contribution to journal › Article › peer-review
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Dysregulated nuclear Lamin B1 in DYT1 dystonia thickens nuclear lamina and disrupts 14-3-3 proteins
Duan, Y., Sepehrimanesh, M., Hosain, M. A., Cui, H., Stagray, J., Shen, X., Xiao, Y., Li, Y., Zhang, C.-L. & Ding, B., Apr 15 2026, In: Cell death discovery. 12, 1, 245.Research output: Contribution to journal › Article › peer-review
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Assembling a coculture system to prepare highly pure induced pluripotent stem cell-derived neurons at late maturation stages
Akter, M., Sepehrimanesh, M., Xu, W. & Ding, B., 2024, In: eNeuro. 11, 7Research output: Contribution to journal › Article › peer-review
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Assembling a Coculture System to Prepare Highly Pure Induced Pluripotent Stem Cell-Derived Neurons at Late Maturation Stages
Akter, M., Sepehrimanesh, M., Xu, W. & Ding, B., Jul 2024, In: eNeuro. 11, 7Research output: Contribution to journal › Article › peer-review
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Lentiviral Delivery of Transcription Factors to Generate Motor Neurons from Human Induced Pluripotent Stem Cells
Sepehrimanesh, M. & Ding, B., 2024, Human Induced Pluripotent Stem Cells. Springer, p. 115-132 18 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter