Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency

Vikram Jakkamsetti; Isaac Marin-Valencia; Qian Ma; Levi B. Good; Tyler Terrill; Karthik Rajasekaran; Kumar Pichumani; Chalermchai Khemtong; M. Ali Hooshyar; Chandrasekhar Sundarrajan; Mulchand S. Patel; Robert M. Bachoo; Craig R. Malloy; Juan M. Pascual

doi:10.1126/scitranslmed.aan0457

Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency

Vikram Jakkamsetti
, Isaac Marin-Valencia
, Qian Ma
, Levi B. Good
, Tyler Terrill
, Karthik Rajasekaran
, Kumar Pichumani
, Chalermchai Khemtong
, M. Ali Hooshyar
, Chandrasekhar Sundarrajan
, Mulchand S. Patel
, Robert M. Bachoo
, Craig R. Malloy
, Juan M. Pascual

Rare Brain Disorders Program
University of Texas Health Science Center
Rare Brain Disorders Clinic and Laboratory
University of Texas Southwestern Medical Center
Laboratory of Developmental Neurobiology
Rockefeller University
Louisiana Tech University
Advanced Imaging Research Center
Department of Neurosurgery
Weill Cornell Medical College
Department of Radiology
Department of Mathematical Sciences
University of Texas at Dallas
SUNY Buffalo
Department of Internal Medicine
Department of Physiology
Department of Pediatrics
Eugene McDermott Center for Human Growth and Development

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	aan0457
Journal	Science Translational Medicine
Volume	11
Issue number	480
DOIs	https://doi.org/10.1126/scitranslmed.aan0457
State	Published - 2019
Externally published	Yes

ASJC Scopus Subject Areas

General Medicine

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Jakkamsetti, V., Marin-Valencia, I., Ma, Q., Good, L. B., Terrill, T., Rajasekaran, K., Pichumani, K., Khemtong, C., Hooshyar, M. A., Sundarrajan, C., Patel, M. S., Bachoo, R. M., Malloy, C. R., & Pascual, J. M. (2019). Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency. Science Translational Medicine, 11(480), Article aan0457. https://doi.org/10.1126/scitranslmed.aan0457

Jakkamsetti, V, Marin-Valencia, I, Ma, Q, Good, LB, Terrill, T, Rajasekaran, K, Pichumani, K, Khemtong, C, Hooshyar, MA, Sundarrajan, C, Patel, MS, Bachoo, RM, Malloy, CR & Pascual, JM 2019, 'Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency', Science Translational Medicine, vol. 11, no. 480, aan0457. https://doi.org/10.1126/scitranslmed.aan0457

@article{c0d65150b5c7418f96e2b9fa27e5dc77,

title = "Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency",

author = "Vikram Jakkamsetti and Isaac Marin-Valencia and Qian Ma and Good, \{Levi B.\} and Tyler Terrill and Karthik Rajasekaran and Kumar Pichumani and Chalermchai Khemtong and Hooshyar, \{M. Ali\} and Chandrasekhar Sundarrajan and Patel, \{Mulchand S.\} and Bachoo, \{Robert M.\} and Malloy, \{Craig R.\} and Pascual, \{Juan M.\}",

year = "2019",

doi = "10.1126/scitranslmed.aan0457",

language = "English",

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AU - Jakkamsetti, Vikram

AU - Marin-Valencia, Isaac

AU - Ma, Qian

AU - Good, Levi B.

AU - Terrill, Tyler

AU - Rajasekaran, Karthik

AU - Pichumani, Kumar

AU - Khemtong, Chalermchai

AU - Hooshyar, M. Ali

AU - Sundarrajan, Chandrasekhar

AU - Patel, Mulchand S.

AU - Bachoo, Robert M.

AU - Malloy, Craig R.

AU - Pascual, Juan M.

PY - 2019

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DO - 10.1126/scitranslmed.aan0457

M3 - Article

SN - 1946-6234

VL - 11

JO - Science Translational Medicine

JF - Science Translational Medicine

IS - 480

M1 - aan0457

ER -

Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency

ASJC Scopus Subject Areas

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