Discovery Phase Agrochemical Predictive Safety Assessment Using High Content In Vitro Data to Estimate an In Vivo Toxicity Point of Departure

Enrica Bianchi; Eduardo Costa; Joshua Harrill; Paul Deford; Jessica LaRocca; Wei Chen; Zachary Sutake; Audrey Lehman; Anthony Pappas-Garton; Eric Sherer; Connor Moreillon; Shreedharan Sriram; Andi Dhroso; Kamin Johnson

doi:10.1021/acs.jafc.4c03094

Discovery Phase Agrochemical Predictive Safety Assessment Using High Content In Vitro Data to Estimate an In Vivo Toxicity Point of Departure

Enrica Bianchi
, Eduardo Costa
, Joshua Harrill
, Paul Deford
, Jessica LaRocca
, Wei Chen
, Zachary Sutake
, Audrey Lehman
, Anthony Pappas-Garton
, Eric Sherer
, Connor Moreillon
, Shreedharan Sriram
, Andi Dhroso
, Kamin Johnson

Corteva Agriscience
Corteva Agriscience do Brasil Ltda.
U.S. Environmental Protection Agency

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	17099-17120
Number of pages	22
Journal	Journal of Agricultural and Food Chemistry
Volume	72
Issue number	30
DOIs	https://doi.org/10.1021/acs.jafc.4c03094
State	Published - Jul 31 2024
Externally published	Yes

ASJC Scopus Subject Areas

General Chemistry
General Agricultural and Biological Sciences

Keywords

agrochemical
cell painting
discovery process
in vitro to in vivo extrapolation (IVIVE)
physiologically based pharmacokinetic modeling
toxicogenomics

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10.1021/acs.jafc.4c03094

Cite this

Bianchi, E., Costa, E., Harrill, J., Deford, P., LaRocca, J., Chen, W., Sutake, Z., Lehman, A., Pappas-Garton, A., Sherer, E., Moreillon, C., Sriram, S., Dhroso, A., & Johnson, K. (2024). Discovery Phase Agrochemical Predictive Safety Assessment Using High Content In Vitro Data to Estimate an In Vivo Toxicity Point of Departure. Journal of Agricultural and Food Chemistry, 72(30), 17099-17120. https://doi.org/10.1021/acs.jafc.4c03094

Bianchi, E, Costa, E, Harrill, J, Deford, P, LaRocca, J, Chen, W, Sutake, Z, Lehman, A, Pappas-Garton, A, Sherer, E, Moreillon, C, Sriram, S, Dhroso, A & Johnson, K 2024, 'Discovery Phase Agrochemical Predictive Safety Assessment Using High Content In Vitro Data to Estimate an In Vivo Toxicity Point of Departure', Journal of Agricultural and Food Chemistry, vol. 72, no. 30, pp. 17099-17120. https://doi.org/10.1021/acs.jafc.4c03094

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AU - Bianchi, Enrica

AU - Costa, Eduardo

AU - Harrill, Joshua

AU - Deford, Paul

AU - LaRocca, Jessica

AU - Chen, Wei

AU - Sutake, Zachary

AU - Lehman, Audrey

AU - Pappas-Garton, Anthony

AU - Sherer, Eric

AU - Moreillon, Connor

AU - Sriram, Shreedharan

AU - Dhroso, Andi

AU - Johnson, Kamin

PY - 2024/7/31

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KW - agrochemical

KW - cell painting

KW - discovery process

KW - in vitro to in vivo extrapolation (IVIVE)

KW - physiologically based pharmacokinetic modeling

KW - toxicogenomics

UR - https://www.scopus.com/pages/publications/85199287739

UR - https://www.scopus.com/pages/publications/85199287739#tab=citedBy

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Discovery Phase Agrochemical Predictive Safety Assessment Using High Content In Vitro Data to Estimate an In Vivo Toxicity Point of Departure

ASJC Scopus Subject Areas

Keywords

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