Identification of a Broad-Spectrum Viral Inhibitor Targeting a Novel Allosteric Site in the RNA-Dependent RNA Polymerases of Dengue Virus and Norovirus

Dongrong Yi; Quanjie Li; Lili Pang; Yujia Wang; Yongxin Zhang; Zhaojun Duan; Chen Liang; Shan Cen

doi:10.3389/fmicb.2020.01440

Identification of a Broad-Spectrum Viral Inhibitor Targeting a Novel Allosteric Site in the RNA-Dependent RNA Polymerases of Dengue Virus and Norovirus

Dongrong Yi
, Quanjie Li
, Lili Pang
, Yujia Wang
, Yongxin Zhang
, Zhaojun Duan
, Chen Liang
, Shan Cen

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College
Chinese Center for Disease Control and Prevention
Lady Davis Institute-Jewish General Hospital
Chinese Academy of Medical Sciences and Peking Union Medical College

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	1440
Journal	Frontiers in Microbiology
Volume	11
DOIs	https://doi.org/10.3389/fmicb.2020.01440
State	Published - Jun 25 2020
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus Subject Areas

Microbiology
Microbiology (medical)

Keywords

RNA-dependent RNA polymerase
allosteric site
antiviral agents
dengue virus
norovirus
re-emerging viruses
structure-based virtual screening
virus replication

Access to Document

10.3389/fmicb.2020.01440

Cite this

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title = "Identification of a Broad-Spectrum Viral Inhibitor Targeting a Novel Allosteric Site in the RNA-Dependent RNA Polymerases of Dengue Virus and Norovirus",

keywords = "RNA-dependent RNA polymerase, allosteric site, antiviral agents, dengue virus, norovirus, re-emerging viruses, structure-based virtual screening, virus replication",

author = "Dongrong Yi and Quanjie Li and Lili Pang and Yujia Wang and Yongxin Zhang and Zhaojun Duan and Chen Liang and Shan Cen",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2020 Yi, Li, Pang, Wang, Zhang, Duan, Liang and Cen.",

year = "2020",

month = jun,

day = "25",

doi = "10.3389/fmicb.2020.01440",

language = "English",

volume = "11",

journal = "Frontiers in Microbiology",

issn = "1664-302X",

}

TY - JOUR

T1 - Identification of a Broad-Spectrum Viral Inhibitor Targeting a Novel Allosteric Site in the RNA-Dependent RNA Polymerases of Dengue Virus and Norovirus

AU - Yi, Dongrong

AU - Li, Quanjie

AU - Pang, Lili

AU - Wang, Yujia

AU - Zhang, Yongxin

AU - Duan, Zhaojun

AU - Liang, Chen

AU - Cen, Shan

PY - 2020/6/25

Y1 - 2020/6/25

KW - RNA-dependent RNA polymerase

KW - allosteric site

KW - antiviral agents

KW - dengue virus

KW - norovirus

KW - re-emerging viruses

KW - structure-based virtual screening

KW - virus replication

UR - https://www.scopus.com/pages/publications/85088986954

UR - https://www.scopus.com/pages/publications/85088986954#tab=citedBy

U2 - 10.3389/fmicb.2020.01440

DO - 10.3389/fmicb.2020.01440

M3 - Article

AN - SCOPUS:85088986954

SN - 1664-302X

VL - 11

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

M1 - 1440

ER -

Identification of a Broad-Spectrum Viral Inhibitor Targeting a Novel Allosteric Site in the RNA-Dependent RNA Polymerases of Dengue Virus and Norovirus

UN SDGs

ASJC Scopus Subject Areas

Keywords

Access to Document

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