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Increasing protein stability by altering long-range coulombic interactions

  • Gerald R. Grimsley
  • , Kevin L. Shaw
  • , Lanette R. Fee
  • , Roy W. Alston
  • , Beatrice M.P. Huyghues-Despointes
  • , Richard L. Thurlkill
  • , J. Martin Scholtz
  • , C. Nick Pace
  • Texas A and M University
  • Department of Biochemistry and Biophysics, Texas A and M University
  • Texas A&M University

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)1843-1849
Number of pages7
JournalProtein Science
Volume8
Issue number9
DOIs
StatePublished - 1999
Externally publishedYes

ASJC Scopus Subject Areas

  • Biochemistry
  • Molecular Biology

Keywords

  • Electrostatic interactions
  • Histidine pK(a)
  • Protein folding
  • Protein stability
  • Reverse hydrophobic effect
  • Ribonuclease Sa
  • Ribonuclease T1

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